SCHEMBL1990363

SCHEMBL1990363

O=C(NOCc1ccccc1)NOCc1ccccc1

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.69
RAB9A P51151 7/20 0.69
CA12 O43570 1/20 0.51
CA1 P00915 1/20 0.51
CA2 P00918 1/20 0.51
CA9 Q16790 1/20 0.51
ALDH1A1 P00352 3/20 0.50
EPHX2 P34913 1/20 0.50
HDAC3 O15379 1/20 0.49
NCOR2 Q9Y618 1/20 0.49
MAPK1 P28482 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
SLC6A2 P23975 1/20 0.48
SLC6A3 Q01959 1/20 0.48
KMT2A Q03164 1/20 0.48
TDP1 Q9NUW8 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14771799 0.90 NPC1 (0.62) NPC1RAB9ACA12CA1CA2
SCHEMBL9781781 0.88 NPC1 (0.61) NPC1RAB9ACA12CA1CA2
SCHEMBL27705808 0.88 NPC1 (0.61) NPC1RAB9ACA12CA1CA2
SCHEMBL295136 0.87 NPC1 (0.69) NPC1RAB9AALDH1A1EPHX2HDAC3
SCHEMBL7608732 0.87 NPC1 (0.59) NPC1RAB9ACA12CA1CA2
SCHEMBL27537790 0.87 NPC1 (0.59) NPC1RAB9AALDH1A1EPHX2L3MBTL1
SCHEMBL690027 0.87 NPC1 (0.59) NPC1RAB9ACA12CA1CA2
SCHEMBL28230418 0.85 NPC1 (0.57) NPC1RAB9ACA12CA1CA2
SCHEMBL693305 0.85 NPC1 (0.67) NPC1RAB9AALDH1A1EPHX2HDAC3
Hydrochloric Acid SCHEMBL28989899 0.85 NPC1 (0.67) NPC1RAB9AALDH1A1EPHX2HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3269717-B9 POLYMORPHIC AND PSEUDOPOLYMORPHIC FORMS OF PHARMACEUTICAL COMPOUND NXL104 PFIZER IRELAND PHARMACEUTICALS (IE) 2023-08-09 EP disclosed
EP-3269717-B2 POLYMORPHIC AND PSEUDOPOLYMORPHIC FORMS OF PHARMACEUTICAL COMPOUND NXL104 PFIZER IRELAND PHARMACEUTICALS (IE) 2023-06-14 EP disclosed
CN-109824668-A The polymorphic forms and pseudopolymorphic forms of medical compounds 辉瑞爱尔兰制药公司 2019-05-31 CN disclosed
US-20170210742-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT FOREST LABORATORIES HOLDINGS LTD (BM) 2017-07-27 US disclosed
US-9580424-B2 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt FOREST LABORATORIES HOLDINGS LIMITED (BM) 2017-02-28 US disclosed
CN-102834395-B Polymorphic and pseudopolymorphic forms of a pharmaceutical compound 阿斯利康控股法国有限公司 2016-06-29 CN disclosed
US-20150246920-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT FOREST LABORATORIES HOLDINGS LIMITED (BM) 2015-09-03 US disclosed
US-9062053-B2 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-Diazabicyclo[3,2,1]octane-2-carboxamide sodium salt FOREST LABORATORIES HOLDINGS LIMITED (BM) 2015-06-23 US disclosed
CN-104592229-A Polymorphic and pseudopolymorphic forms of a pharmaceutical compound ASTRA ZENECA HOLDING FRANCE SAS 2015-05-06 CN disclosed
US-20140349967-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT FOREST LABORATORIES HOLDINGS LIMITED (BM) 2014-11-27 US disclosed
US-8835455-B2 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) 2014-09-16 US disclosed
US-20130267480-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) 2013-10-10 US disclosed
US-8471025-B2 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) 2013-06-25 US disclosed
CN-102834395-A Polymorphic and pseudopolymorphic forms of a pharmaceutical compound NOVEXEL SA 2012-12-19 CN disclosed
US-20110152311-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT FOREST LABORATORIES HOLDINGS LTD. (BM) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152311-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT SLC10A6, SLC5A2, SLC5A1 NPC1 3027/4885RAB9A 2273/4885CA12 576/4885
US-20130267480-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT SLC10A6, SLC5A2, SLC5A1 NPC1 3027/4885RAB9A 2273/4885CA12 576/4885
US-20170210742-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT SLC10A6, SLC5A2, SLC5A1 NPC1 3027/4885RAB9A 2273/4885CA12 576/4885
US-20140349967-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT SLC10A6, SLC5A2, SLC5A1 NPC1 3027/4885RAB9A 2273/4885CA12 576/4885
US-20150246920-A1 NOVEL CRYSTALLINE FORMS OF TRANS-7-OXO-6-(SULPHOOXY)-1,6-DIAZABICYCLO[3,2,1]OCTANE-2-CARBOXAMIDE SODIUM SALT SLC10A6, SLC5A2, SLC5A1 NPC1 3027/4885RAB9A 2273/4885CA12 576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.