Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.35 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600491 | 0.79 | TNKS (0.39) | TNKSTNKS2CYP1A2CYP3A4MEN1 | |
| SCHEMBL7535235 | 0.76 | ALDH1A1 (0.40) | TNKSTNKS2P2RX3P2RX2CYP1A2 | |
| SCHEMBL7688428 | 0.75 | LMNA (0.56) | TNKSTNKS2P2RX3CYP1A2CYP3A4 | |
| SCHEMBL482345 | 0.74 | DYRK1A (0.42) | TNKSCYP1A2CYP3A4MEN1LMNA | |
| SCHEMBL24420477 | 0.74 | ALDH1A1 (0.37) | TNKSTNKS2P2RX3P2RX2CYP1A2 | |
| SCHEMBL28660913 | 0.74 | TNKS (0.36) | TNKSTNKS2P2RX3P2RX2CYP1A2 | |
| SCHEMBL23240599 | 0.74 | TNKS (0.36) | TNKSTNKS2P2RX3P2RX2CYP1A2 | |
| SCHEMBL29038509 | 0.73 | DAO (0.63) | TNKSTNKS2ALDH1A1DAOFEN1 | |
| SCHEMBL5805556 | 0.71 | CYP1A2 (0.49) | TNKSTNKS2P2RX3P2RX2CYP1A2 | |
| SCHEMBL29385770 | 0.70 | POLB (0.44) | TNKSTNKS2P2RX3MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002030886-A2 | HETEROCYCLIC ANGIOGENESIS INHIBITORS | MATTHEWS BARRY R (AU) | 2002-04-18 | — | — | WO | claimed |
| WO-2002030886-A2 | HETEROCYCLIC ANGIOGENESIS INHIBITORS | MATTHEWS BARRY R (AU) | 2002-04-18 | — | — | WO | disclosed |