Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASGR1 | P07306 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12209106 | 0.86 | ASGR1 (0.39) | ASGR1CA14HDAC6HDAC1HDAC2 | |
| SCHEMBL7606626 | 0.83 | HDAC6 (0.33) | ASGR1HDAC6HDAC1HDAC2 | |
| SCHEMBL15908023 | 0.82 | CTSD (0.34) | ASGR1CA14HDAC6HDAC1HDAC2 | |
| SCHEMBL6290954 | 0.81 | CHRNB2 (0.40) | — | |
| SCHEMBL29818922 | 0.81 | ASGR1 (0.33) | ASGR1HDAC6HDAC1HDAC2CTSD | |
| SCHEMBL7610203 | 0.81 | ASGR1 (0.33) | ASGR1CA14HDAC6HDAC1HDAC2 | |
| SCHEMBL23562270 | 0.79 | ASGR1 (0.32) | ASGR1HDAC6HDAC1HDAC2CTSD | |
| SCHEMBL27762584 | 0.79 | ASGR1 (0.37) | ASGR1HDAC6HDAC1HDAC2CTSD | |
| SCHEMBL6138236 | 0.79 | ASGR1 (0.32) | ASGR1HDAC6HDAC1HDAC2CTSD | |
| SCHEMBL6290201 | 0.79 | NFKB1 (0.36) | CYP4F2CYP4A11HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |