Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.46 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.45 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.45 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7608810 | 0.79 | HSD17B10 (0.53) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7605577 | 0.79 | HSD17B10 (0.53) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7607267 | 0.76 | PDE7A (0.52) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL7605576 | 0.76 | PDE7A (0.48) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL27581742 | 0.76 | PDE7A (0.75) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL29535654 | 0.74 | HSD17B10 (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL169304 | 0.74 | HSD17B10 (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL19654571 | 0.74 | HSD17B10 (0.67) | PDE7APDE4BPDE4DPDE7BHSD17B10 | |
| SCHEMBL7607866 | 0.74 | PDE7A (0.52) | PDE7APDE4BPDE4DPDE7BTXNRD1 | |
| SCHEMBL10405791 | 0.74 | HSD17B10 (0.72) | PDE7AHSD17B10ALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |