Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 8/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.49 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.49 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | USP10 | Q14694 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27581742 | 0.86 | PDE7A (0.75) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL7605580 | 0.85 | PDE7A (0.58) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL31217501 | 0.82 | TXNRD1 (0.63) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL20379950 | 0.80 | PDE7A (0.56) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL7605579 | 0.80 | PDE7A (0.67) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL7607910 | 0.78 | PDE7A (0.78) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL7610275 | 0.77 | PDE7A (0.78) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL9484826 | 0.74 | HSD17B10 (0.58) | LMNAHSD17B10HSPB1ALDH1A1MAPT | |
| SCHEMBL8308859 | 0.74 | PDE7A (1.00) | PDE7APDE4BPDE4DPDE7BLMNA | |
| SCHEMBL1149232 | 0.74 | PDE7A (0.78) | PDE7APDE4BPDE4DPDE7BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |