Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8857127 | 0.98 | PNMT (0.46) | PNMTDRD2DRD4DRD3HTR6 | |
| Hydrochloric Acid SCHEMBL5346729 | 0.93 | PNMT (0.46) | PNMTDRD2DRD4DRD3HTR6 | |
| Hydrochloric Acid SCHEMBL5357721 | 0.91 | PNMT (0.46) | PNMTDRD2DRD4DRD3HTR6 | |
| SCHEMBL7647636 | 0.90 | PNMT (0.48) | PNMTDRD2DRD4DRD3HTR6 | |
| SCHEMBL7604393 | 0.89 | PNMT (0.47) | PNMTDRD2DRD4DRD3HTR6 | |
| SCHEMBL7613461 | 0.89 | PNMT (0.47) | PNMTDRD2DRD4DRD3HTR6 | |
| Hydrochloric Acid SCHEMBL6558664 | 0.85 | PNMT (0.48) | PNMTDRD2DRD4DRD3HTR6 | |
| SCHEMBL7638914 | 0.83 | PNMT (0.50) | PNMTDRD2DRD4DRD3HTR6 | |
| Hydrochloric Acid SCHEMBL5353742 | 0.78 | PNMT (0.64) | PNMTDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL5352665 | 0.75 | PNMT (0.64) | PNMTDRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403734-B1 | POLYMERIZING ALPHA-OLEFIN BY CONTACTING WITH CATALYST SYSTEM COMPRISING BRIDGED FLUORENYL METALLOCENE CONTAINING METAL OF GROUP 4 OR 5 AND SUITABLE COCATALYST | PHILLIPS PETROLEUM COMPANY | 2002-06-11 | — | — | US | disclosed |
| EP-0524624-B1 | Use of organometallic flurorenyl compounds. | PHILLIPS PETROLEUM CO (US) | 2002-05-15 | — | — | EP | disclosed |
| EP-0666267-B1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM CO (US) | 2001-04-18 | — | — | EP | disclosed |
| US-6162936-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2000-12-19 | — | — | US | disclosed |
| EP-0666267-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-08-09 | — | — | EP | disclosed |
| US-5436305-A | Preparing polymer catalysts by reaction of alkali metal alkyl and fluorenyl in solvent | PHILLIPS PETROLEUM COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| CN-1068829-A | Organometallic fluorenyl compounds and preparation thereof and application | PHILLIPS PETROLEUM CO (US) | 1993-02-10 | — | — | CN | disclosed |
| EP-0524624-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1993-01-27 | — | — | EP | disclosed |