Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 15/20 | 0.49 |
| ▸ | HRH1 | P35367 | 15/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12156869 | 0.85 | HRH2 (0.55) | HRH2HRH1ALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7605519 | 0.84 | TLR8 (0.46) | SMN1; SMN2 | |
| SCHEMBL7603640 | 0.81 | HRH1 (0.34) | HRH2HRH1ALDH1A1HRH3 | |
| SCHEMBL7604063 | 0.81 | TACR1 (0.40) | HRH2HRH1 | |
| SCHEMBL14670199 | 0.80 | HRH2 (0.56) | HRH2HRH1ALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL9051052 | 0.80 | ALDH1A1 (0.56) | HRH2HRH1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13845060 | 0.79 | HRH2 (0.53) | HRH2HRH1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27629332 | 0.79 | HRH2 (0.59) | HRH2HRH1ALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL7604181 | 0.79 | SMN1; SMN2 (0.55) | HRH2HRH1GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL27445572 | 0.79 | ALDH1A1 (0.58) | HRH2HRH1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927173-B1 | SUBSTITUTED [2-(1-PIPERAZINYL)ETHOXY]METHYL | UCB SA (BE) | 2002-06-12 | — | — | EP | claimed |
| US-6140501-A | CHEMICAL INTERMEDIATES | UCB, S.A. (BE) | 2000-10-31 | — | — | US | claimed |
| US-6255487-B1 | PREPARING 2-(2-(4-((4-CHLOROPHENYL)PHENYLMETHYL)-1-PIPER-AZINYL)ETHOXY)ACETIC ACID VIA REACTING SUBSTITUTED (2-((1-PIPERAZINYL)ETHOXY)METHYL COMPOUND WITH A DIPHENYLMETHYL HALIDE, THEN HYDROLYZING IN ALCOHOLIC MEDIUM WITH ACID/BASE | UCB, S.A. (BE) | 2001-07-03 | — | — | US | disclosed |
| US-6140501-A | CHEMICAL INTERMEDIATES | UCB, S.A. (BE) | 2000-10-31 | — | — | US | disclosed |