Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.75 |
| ▸ | PKM | P14618 | 1/20 | 0.75 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 8/20 | 0.62 |
| ▸ | RAB9A | P51151 | 7/20 | 0.62 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.54 |
| ▸ | RELA | Q04206 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27296254 | 0.92 | KMT2A (0.87) | KMT2APKMSIRT6MAPTALDH1A1 | |
| SCHEMBL30772317 | 0.92 | KMT2A (0.87) | KMT2APKMSIRT6MAPTALDH1A1 | |
| SCHEMBL11590256 | 0.88 | NPC1 (0.66) | KMT2APKMNPC1RAB9AMAPT | |
| Benzoylpas SCHEMBL563122 | 0.86 | KMT2A (1.00) | KMT2APKMSIRT6NPC1RAB9A | |
| SCHEMBL27379558 | 0.85 | KMT2A (0.75) | KMT2APKMSIRT6MAPTMEN1 | |
| Benzoylpas SCHEMBL9770542 | 0.84 | KMT2A (0.97) | KMT2APKMSIRT6NPC1RAB9A | |
| Benzoylpas SCHEMBL29353120 | 0.84 | KMT2A (0.97) | KMT2APKMSIRT6NPC1RAB9A | |
| Benzoylpas SCHEMBL8748163 | 0.84 | KMT2A (0.97) | KMT2APKMSIRT6NPC1RAB9A | |
| SCHEMBL16592199 | 0.84 | KMT2A (0.69) | KMT2APKMSIRT6NPC1RAB9A | |
| SCHEMBL14363264 | 0.84 | KMT2A (0.60) | KMT2APKMNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-B1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | claimed |
| CN-1243724-C | Amide derivatives which are useful as cell factor inhibitors | ASTRA ZENECA LTD (SE) | 2006-03-01 | — | — | CN | disclosed |
| EP-1102743-B1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2002-07-24 | — | — | EP | disclosed |