Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 9/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5060524 | 0.91 | TBXAS1 (0.46) | FOLH1TBXAS1ANPEPERAP2ERAP1 | |
| SCHEMBL1377622 | 0.89 | ALDH1A1 (0.43) | CYP1A2FOLH1FDPS | |
| SCHEMBL1377537 | 0.80 | FOLH1 (0.52) | CYP1A2CYP2D6FOLH1 | |
| SCHEMBL5059776 | 0.80 | TBXAS1 (0.50) | TBXAS1ANPEPERAP2ERAP1NAPRT | |
| SCHEMBL5057928 | 0.80 | ANPEP (0.52) | TBXAS1ANPEPERAP2ERAP1NAPRT | |
| SCHEMBL5057902 | 0.79 | TBXAS1 (0.55) | TBXAS1ANPEPERAP2ERAP1 | |
| SCHEMBL7606078 | 0.79 | SMN1; SMN2 (0.41) | CYP1A2FOLH1FDPS | |
| SCHEMBL5052953 | 0.78 | FDPS (0.51) | CYP1A2CYP2D6FDPS | |
| SCHEMBL5054254 | 0.78 | ANPEP (0.47) | TBXAS1ANPEPERAP2ERAP1FDPS | |
| SCHEMBL2368223 | 0.77 | SMN1; SMN2 (0.42) | CYP1A2CYP2D6FDPSKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002515040-A | — | — | 2002-05-21 | — | — | JP | claimed |
| EP-0954295-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1999-11-10 | — | — | EP | claimed |
| WO-1997048409-A1 | METHODS OF CANCER TREATMENT USING NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1997-12-24 | — | — | WO | claimed |