Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10886471 | 0.92 | APP (0.51) | APPMAOBMAPTALDH1A1CYP1A2 | |
| SCHEMBL6935103 | 0.90 | MAPT (0.44) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7606361 | 0.89 | APP (0.43) | APPMAOBMAPTALDH1A1CYP1A2 | |
| SCHEMBL6290909 | 0.88 | HTT (0.50) | APPMAOBMAPTALDH1A1CYP1A2 | |
| SCHEMBL10884505 | 0.84 | MAPT (0.47) | APPMAOBMAPTALDH1A1CYP1A2 | |
| SCHEMBL7615727 | 0.84 | CYP1A2 (0.58) | MAPK10MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6935668 | 0.84 | MAPT (0.44) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6933786 | 0.84 | PSD (0.44) | MAPTALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16913325 | 0.81 | MAPK10 (0.50) | MAPK10MAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7607849 | 0.81 | CYP1A2 (0.61) | APPMAOBMAPK10MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888313-B1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AG (DE) | 2002-04-17 | — | — | EP | disclosed |
| US-6200970-B1 | FOR TREATING A DISEASE ASSOCIATED WITH OVERSTIMULATION OF AN AMPA RECEPTOR, OR HYPERACTIVITY OF AN EXCITATORY AMINO ACID | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-03-13 | — | — | US | disclosed |
| EP-0888313-A1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028135-A1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-08-07 | — | — | WO | disclosed |