Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10886471 | 0.91 | APP (0.51) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL7606361 | 0.88 | APP (0.43) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL7609618 | 0.88 | APP (0.43) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL6293666 | 0.85 | ALDH1A1 (0.60) | TDP1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL6290864 | 0.80 | ALDH1A1 (0.60) | TDP1KMT2AMEN1MAPTCYP1A2 | |
| SCHEMBL7498251 | 0.79 | KMT2A (0.44) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL6935103 | 0.79 | MAPT (0.44) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL7439628 | 0.79 | PDE4D (0.44) | KMT2AMEN1MAPTALDH1A1APP | |
| SCHEMBL6937957 | 0.78 | MAPT (0.44) | HTTTDP1KMT2AMEN1MAPT | |
| SCHEMBL6935668 | 0.78 | MAPT (0.44) | HTTTDP1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887867-B2 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. (US) | 2005-05-03 | — | — | US | disclosed |
| US-20020025958-A1 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. | 2002-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020025958-A1 | 5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors | GRIN2A, GRIN3A, GABRE | HTT 2267/4885TDP1 3937/4885KMT2A 719/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.