Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.67 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.57 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.50 |
| ▸ | WNT3A | P56704 | 2/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL50742 | 0.80 | PBRM1 (1.00) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL29531272 | 0.80 | PBRM1 (1.00) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL15577111 | 0.80 | PBRM1 (0.67) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL6156917 | 0.79 | PBRM1 (0.61) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL8700747 | 0.79 | PBRM1 (0.52) | PBRM1GPR84ALDH1A1KMT2AATM | |
| Hydrochloric Acid SCHEMBL9481167 | 0.79 | PBRM1 (0.96) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL12215128 | 0.77 | PBRM1 (0.73) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL30353966 | 0.77 | GPR84 (0.71) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL72811 | 0.77 | GPR84 (0.71) | PBRM1GPR84ALDH1A1KMT2AATM | |
| SCHEMBL27320955 | 0.77 | PBRM1 (0.67) | PBRM1GPR84ALDH1A1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |