Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.56 |
| ▸ | WNT3A | P56704 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.53 |
| ▸ | HTR3B | O95264 | 1/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353966 | 1.00 | GPR84 (0.71) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| Hydrochloric Acid SCHEMBL6073132 | 0.98 | GPR84 (0.69) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL17452062 | 0.87 | CFTR (0.60) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL29504738 | 0.85 | GPR84 (0.67) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL761480 | 0.85 | GPR84 (0.67) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL64182 | 0.83 | GPR84 (0.77) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL2028344 | 0.83 | GPR84 (1.00) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL4954977 | 0.83 | GPR84 (0.77) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| SCHEMBL27762348 | 0.83 | GPR84 (0.64) | GPR84ALDH1A1PBRM1ATMKMT2A | |
| Hydrochloric Acid SCHEMBL6099324 | 0.83 | GPR84 (0.65) | GPR84ALDH1A1PBRM1ATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111057062-A | Preparation method and application of furan and indole-based aryloxy bifunctional synthesis spiro indolone | 江苏意诺飞生物科技有限公司 | 2020-04-24 | — | — | CN | claimed |
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG | 2007-04-26 | — | — | US | claimed |
| US-7166637-B2 | Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG (DE) | 2007-01-23 | — | — | US | claimed |
| US-20040147759-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | ELBION AG (DE) | 2004-07-29 | — | — | US | claimed |
| EP-0266730-B1 | Esters of hexadydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds | MERRELL DOW PHARMA (US) | 1994-08-10 | — | — | EP | claimed |
| EP-0266730-A1 | Esters of hexadydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-11 | — | — | EP | claimed |
| US-20240417379-A1 | P2X4 RECEPTOR ANTAGONIST | NIPPON CHEMIPHAR CO., LTD (JP) | 2024-12-19 | — | — | US | disclosed |
| US-12116351-B2 | P2X4 receptor antagonist | NIPPON CHEMIPHAR CO., LTD (JP) | 2024-10-15 | — | — | US | disclosed |
| WO-2024130095-A9 | COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2024-08-02 | — | — | WO | disclosed |
| US-11891386-B2 | Indole compounds and their use | ARIAGEN, INC. (CA) | 2024-02-06 | — | — | US | disclosed |
| CN-111566100-B | Pyrimidine compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2023-10-27 | — | — | CN | disclosed |
| US-11787783-B2 | Heparanase inhibitors and use thereof | Beta Therapeutics Pty Ltd (AU) | 2023-10-17 | — | — | US | disclosed |
| US-11787783-B2 | Heparanase inhibitors and use thereof | Beta Therapeutics Pty Ltd (AU) | 2023-10-17 | — | — | US | disclosed |
| US-4797406-A | MIGRAINES, ANTIARRHYTHMIA AGENTS | SANDOZ LTD. (CH) | 1989-01-10 | — | — | US | disclosed |
| US-4789673-A | ANTISEROTONINE AGENTS | NOVARTIS AG (CH) | 1988-12-06 | — | — | US | disclosed |
| US-4783478-A | Treatment of emesis, nausea and vomiting | BEECHAM GROUP P.L.C. (GB) | 1988-11-08 | — | — | US | disclosed |
| US-4721720-A | IRRITABLE BOWEL SYNDROME | BEECHAM GROUP P.L.C. | 1988-01-26 | — | — | US | disclosed |
| EP-0201165-A2 | Medicaments for the treatment of emesis | BEECHAM GROUP PLC (GB) | 1986-11-12 | — | — | EP | disclosed |
| US-3980668-A | Anti-arrhythimic 5-endo-(3-indolecarbonyloxy)-N-[amino-(lower)alkyl]bicyclo[2,2,1]heptane-2,3-di-endo-carboxylic acid imides | BRISTOL-MYERS COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
| US-3980667-A | Anti-arrhythmic 5-endo-substituted oxy-N-(aminoloweralkyl)bicycle [2.2.2.]oc | BRISTOL-MYERS COMPANY (US) | 1976-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147759-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | GPR84 863/4885ALDH1A1 1187/4885PBRM1 4087/4885 |
| US-20240417379-A1 | P2X4 RECEPTOR ANTAGONIST | P2RX7, P2RX1, P2RX2 | GPR84 121/4885ALDH1A1 3045/4885PBRM1 1521/4885 |
| US-12116351-B2 | P2X4 receptor antagonist | P2RX7, P2RX1, P2RX2 | GPR84 93/4885ALDH1A1 3019/4885PBRM1 2167/4885 |
| US-11891386-B2 | Indole compounds and their use | IDO1, IDO2, INMT | GPR84 801/4885ALDH1A1 1731/4885PBRM1 3324/4885 |
| US-11787783-B2 | Heparanase inhibitors and use thereof | HPSE, HEXD, ENGASE | GPR84 1599/4885ALDH1A1 1394/4885PBRM1 3026/4885 |
| US-20070093531-A1 | Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them | PDE4B, PDE4A, PDE4D | GPR84 1601/4885ALDH1A1 1815/4885PBRM1 4242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.