Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609672 | 0.79 | PBRM1 (0.67) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL29113776 | 0.71 | ALDH1A1 (0.56) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL1586378 | 0.71 | ALDH1A1 (0.56) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL8700750 | 0.71 | SMN1; SMN2 (0.51) | KMT2AALDH1A1ALOX15MEN1LMNA | |
| SCHEMBL50742 | 0.70 | PBRM1 (1.00) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL29531272 | 0.70 | PBRM1 (1.00) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL15577111 | 0.70 | PBRM1 (0.67) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL64182 | 0.70 | GPR84 (0.77) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL17232878 | 0.70 | PBRM1 (0.71) | PBRM1KMT2AALDH1A1NR4A2CREBBP | |
| SCHEMBL19459867 | 0.70 | ALOX5 (0.63) | KMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846942-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1998-12-08 | — | — | US | disclosed |
| US-5593967-A | Cholecystokinin antagonists, their preparation and therapeutic use | WARNER-LAMBERT COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1992004045-A1 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |