⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350295 | 0.77 | — | — | |
| SCHEMBL27933672 | 0.73 | TDP1 (0.39) | — | |
| SCHEMBL28194790 | 0.72 | — | — | |
| SCHEMBL6345896 | 0.69 | — | — | |
| SCHEMBL27640631 | 0.69 | — | — | |
| Dimethylamine SCHEMBL385867 | 0.68 | TSHR (0.39) | — | |
| SCHEMBL25755075 | 0.67 | ATM (0.44) | — | |
| SCHEMBL9232313 | 0.67 | TYK2 (0.40) | — | |
| SCHEMBL8012516 | 0.66 | RAB9A (0.40) | — | |
| SCHEMBL197196 | 0.65 | PCSK9 (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |
| US-20230365544-A1 | SMALL MOLECULE INHIBITORS OF CALCIUM CHANNEL ACTIVITY AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH | 2023-11-16 | — | — | US | disclosed |
| US-20230340018-A1 | MPRO CYSTEINE PROTEASE INHIBITORS | ANIXA BIOSCIENCES, INC. | 2023-10-26 | — | — | US | disclosed |
| EP-3582783-B1 | 7-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME | TREVENA INC (US) | 2023-06-07 | — | — | EP | disclosed |
| CN-110300578-B | Compounds for the treatment of respiratory diseases in cattle or pigs | 英特维特国际股份有限公司 | 2022-12-13 | — | — | CN | disclosed |
| EP-4086249-A2 | 6-MEMBERED AZA-HETEROCYCLIC CONTAINING DELTA-OPIOID RECEPTOR MODULATING COMPOUNDS, METHODS OF USING AND MAKING THE SAME | Trevena, Inc. (US) | 2022-11-09 | — | — | EP | disclosed |
| CN-107466232-B | Methods of treating or preventing RAS-mediated diseases | ADT制药有限责任公司 | 2021-06-29 | — | — | CN | disclosed |
| CN-112047909-A | Indenyl compound, pharmaceutical composition and medical application thereof | ADT制药有限责任公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-107531615-B | Indenyl compound, pharmaceutical composition and medical application thereof | ADT制药有限责任公司 | 2020-09-04 | — | — | CN | disclosed |
| EP-2970145-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | BROAD INST INC (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-2284155-A2 | Substituted tetracycline compounds | Paratek Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| EP-2269978-A2 | Substituted tetracycline compounds | Paratek Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2269985-A2 | Substituted tetracycline compounds | Paratek Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2269991-A2 | Substituted tetracycline compounds | Paratek Pharmaceuticals, Inc. (US) | 2011-01-05 | — | — | EP | disclosed |
| EP-2033950-A1 | Substituted tetracycline compounds | Paratek Pharmaceuticals, Inc. (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20070282101-A1 | Indazole compounds | ABBVIE INC. | 2007-12-06 | — | — | US | disclosed |
| EP-1807387-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS | Paratek Pharmaceuticals, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20060166945-A1 | Substituted tetracycline compounds | PARATEK PHARMACEUTICALS, INC. (US) | 2006-07-27 | — | — | US | disclosed |
| WO-2006047756-A2 | SUBSTITUTED TETRACYCLINE COMPOUNDS | PARATEK PHARMACEUTICALS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
| CN-1084169-A | New phenylpyrrole derivative and its production and use | SMITHKLINE BEECHAM PLC (GB) | 1994-03-23 | — | — | CN | disclosed |