SCHEMBL7612293

SCHEMBL7612293

Cc1ccccc1CNC(=O)c1cccc(NC(=O)c2ccccc2-c2ccc(C(F)(F)F)cc2)c1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.52
TP53 P04637 1/20 0.52
APOB P04114 4/20 0.51
KMT2A Q03164 1/20 0.51
MTTP P55157 5/20 0.50
BCHE P06276 2/20 0.50
ALDH1A1 P00352 1/20 0.50
HPGD P15428 1/20 0.50
MAPT P10636 2/20 0.49
LMNA P02545 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
KDM4E B2RXH2 1/20 0.49
GAA P10253 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7607921 0.90 APOB (0.55) TP53APOBMTTPBCHEALDH1A1
SCHEMBL7617123 0.90 MTTP (0.55) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7608575 0.88 MTTP (0.54) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7612923 0.88 CHRNB2 (0.58) PPARGTP53APOBMTTPBCHE
SCHEMBL7607440 0.87 MTTP (0.57) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7607281 0.87 LMNA (0.55) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7612180 0.86 MTTP (0.61) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7605798 0.86 LMNA (0.54) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7613057 0.86 MTTP (0.54) PPARGAPOBMTTPALDH1A1HPGD
SCHEMBL7612283 0.85 MTTP (0.54) PPARGAPOBMTTPALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments BOEHRINGER INGELHEIM PHARMA KG (DE) 2002-03-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020032238-A1 Biphenylcarboxylic acid amides, the preparation thereof and the use thereof as medicaments MTTP, CETP, FABP1 PPARG 86/4885TP53 4688/4885APOB 45/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.