Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.46 |
| ▸ | NOS2 | P35228 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 2/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7613859 | 0.98 | LMNA (0.47) | LMNAHSD17B10NOS3NOS2EPHX1 | |
| SCHEMBL29176481 | 0.84 | AOC3 (0.47) | LMNAHSD17B10NOS3NOS2EPHX1 | |
| SCHEMBL6198748 | 0.81 | POLB (0.43) | LMNANOS3NOS2EPHX1ALDH1A1 | |
| SCHEMBL3109832 | 0.81 | EPHX1 (0.46) | NOS3NOS2EPHX1SMN1; SMN2 | |
| Fenbutyramide SCHEMBL1477997 | 0.79 | EPHX1 (0.63) | LMNAHSD17B10EPHX1ALDH1A1POLB | |
| Fenbutyramide SCHEMBL232920 | 0.79 | EPHX1 (0.63) | LMNAHSD17B10EPHX1ALDH1A1POLB | |
| SCHEMBL5052396 | 0.79 | LMNA (0.48) | LMNAHSD17B10NOS3NOS2EPHX1 | |
| Fenbutyramide SCHEMBL1478462 | 0.79 | EPHX1 (0.63) | LMNAHSD17B10EPHX1ALDH1A1POLB | |
| Fenbutyramide SCHEMBL15995561 | 0.78 | EPHX1 (0.61) | LMNAHSD17B10EPHX1ALDH1A1POLB | |
| SCHEMBL18888546 | 0.77 | ALDH1A1 (0.54) | LMNAALDH1A1POLBCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724435-B1 | AMIDINO DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS | SEARLE & CO (US) | 2002-08-14 | — | — | EP | claimed |