Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | GAA | P10253 | 8/20 | 0.58 |
| ▸ | GLA | P06280 | 7/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | STS | P08842 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380623 | 0.99 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| Lithium Ion SCHEMBL1871467 | 0.97 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL4610784 | 0.91 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL20703812 | 0.87 | ALDH1A1 (0.69) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL140039 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL4610846 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL29391759 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL7058731 | 0.84 | ALDH1A1 (0.66) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| Phosphoric Acid SCHEMBL9224251 | 0.83 | ALDH1A1 (0.64) | ALDH1A1KDM4EHSD17B10HPGDGAA | |
| SCHEMBL1023154 | 0.83 | ALDH1A1 (0.68) | ALDH1A1KDM4EHSD17B10HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842181-B1 | MEMBRANE-PERMEANT SECOND MESSENGERS | UNIV CALIFORNIA (US) | 2002-10-02 | — | — | EP | disclosed |
| US-5866548-A | ACTIVATION BY ULTRAVIOLET LIGHT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-02-02 | — | — | US | disclosed |
| EP-0842181-A4 | MEMBRANE-PERMEANT SECOND MESSENGERS | UNIV CALIFORNIA (US) | 1998-11-25 | — | — | EP | disclosed |
| US-5834436-A | CYCLOHEXANES SUBSTITUTED BY ACYLOXYALKYL PHOSPHATE ESTERS AS CARRIERS WHICH CAN PENETRATE CELL MEMBRANES WITHOUT DISRUPTING IT; | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-11-10 | — | — | US | disclosed |
| WO-1998026786-A1 | CAGED MEMBRANE-PERMEANT INOSITOL PHOSPHATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-06-25 | — | — | WO | disclosed |
| EP-0842181-A1 | MEMBRANE-PERMEANT SECOND MESSENGERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-05-20 | — | — | EP | disclosed |
| US-5693521-A | USING ACETOXYALKYL ESTER OF ADENOSINE(OR GUANOSINE)-3',5'-CYCLIC MONNOPHOSPHATE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-12-02 | — | — | US | disclosed |
| WO-1996040695-A1 | MEMBRANE-PERMEANT SECOND MESSENGERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |
| WO-1994023724-A1 | MEMBRANE-PERMEANT SECOND MESSENGERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-10-27 | — | — | WO | disclosed |