Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | PTGIR | P43119 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779182 | 0.85 | MTNR1A (0.46) | MTNR1AMTNR1BPOLBPARP1LMNA | |
| SCHEMBL27587717 | 0.85 | MTNR1A (0.46) | MTNR1AMTNR1BPARP1LMNAHSD17B2 | |
| SCHEMBL7616834 | 0.85 | LMNA (0.50) | KDM4ELMNARAB9APTPN1MEN1 | |
| SCHEMBL28382188 | 0.84 | PARP1 (0.56) | MTNR1AMTNR1BPARP1HSD17B2HSD17B1 | |
| SCHEMBL6438589 | 0.82 | PTPN1 (0.49) | KDM4EPOLBRAB9APTPN1KMT2A | |
| SCHEMBL7613732 | 0.78 | AKR1C3 (0.54) | KDM4EPOLBLMNAHSD17B2HSD17B1 | |
| SCHEMBL6440646 | 0.77 | GRIK1 (0.44) | KDM4ELMNARAB9APTGIRNOTUM | |
| SCHEMBL27605751 | 0.77 | TP53 (0.46) | MTNR1AMTNR1BKDM4EPARP1HSD17B2 | |
| SCHEMBL6589199 | 0.77 | HTT (0.47) | KDM4EPOLBLMNARAB9AMEN1 | |
| SCHEMBL7621249 | 0.76 | PTPN1 (0.50) | KDM4ELMNAPTPN1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906273-B1 | PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH AS (DK) | 2002-10-16 | — | — | EP | disclosed |
| US-6417393-B1 | TREATMENT OF SICKLE-CELL ANEMIA, BRAIN EDEMA FROM TUMORS OR ISCHEMIA, DIARRHEA, AND GLAUCOMA; HYPOTENSIVE, WOUND HEALING, ANTIINFLAMMATORY AND ANTIALLERGEN AGENTS | NEUROSEARCH A/S (DK) | 2002-07-09 | — | — | US | disclosed |
| EP-0906273-A1 | PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045400-A1 | PHENYL DERIVATIVES CONTAINING AN ACIDIC GROUP, THEIR PREPARATION AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 1997-12-04 | — | — | WO | disclosed |