Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.32 |
| ▸ | SSTR1 | P30872 | 2/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27928621 | 0.84 | ALDH1A1 (0.33) | EPHX2ALDH1A1SIGMAR1EPHX1SSTR1 | |
| SCHEMBL15114600 | 0.84 | FPR2 (0.41) | EPHX2ALDH1A1SIGMAR1EPHX1SSTR1 | |
| SCHEMBL8806885 | 0.81 | KMT2A (0.43) | EPHX2ALDH1A1SIGMAR1EPHX1KDM4E | |
| SCHEMBL789907 | 0.80 | EPHX1 (0.55) | EPHX2ALDH1A1EPHX1KDM4EKMT2A | |
| SCHEMBL788997 | 0.79 | EPHX2 (0.36) | EPHX2EPHX1KDM4E | |
| SCHEMBL8559580 | 0.77 | HPGD (0.52) | ALDH1A1KMT2A | |
| SCHEMBL16072939 | 0.77 | EPHX2 (0.41) | EPHX2ALDH1A1SIGMAR1EPHX1KDM4E | |
| SCHEMBL27343743 | 0.74 | EPHX1 (0.48) | EPHX2SIGMAR1EPHX1HDAC4HDAC1 | |
| SCHEMBL25537481 | 0.74 | EPHX2 (0.39) | EPHX2ALDH1A1SIGMAR1EPHX1KDM4E | |
| SCHEMBL2597299 | 0.73 | EPHX1 (0.53) | EPHX2ALDH1A1EPHX1HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616074-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | Array Biopharma, Inc. (US) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012037393-A1 | PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-03-22 | — | — | WO | disclosed |