Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | FABP2 | P12104 | 2/20 | 0.49 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11516039 | 0.96 | PPARA (0.51) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL7616014 | 0.89 | PPARA (0.53) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL8340626 | 0.85 | PPARA (0.58) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL9255616 | 0.85 | PPARG (0.43) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL11369656 | 0.81 | SMN1; SMN2 (0.42) | CYP1A2MAPTCYP2C19MEN1KMT2A | |
| SCHEMBL14541729 | 0.78 | PPARA (0.66) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL11144161 | 0.77 | PPARA (0.60) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL4252166 | 0.76 | PPARA (0.64) | PPARACYP1A2CYP3A4MAPTCYP2C19 | |
| SCHEMBL15439030 | 0.75 | KMT2A (0.44) | CYP1A2MAPTCYP2C19MEN1CYP2D6 | |
| SCHEMBL9785247 | 0.73 | L3MBTL1 (0.51) | CYP1A2CYP3A4MAPTCYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1012137-B1 | AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS | PROCTER & GAMBLE (US) | 2002-11-06 | — | — | EP | disclosed |
| EP-1012137-A1 | AROMATIC C 16?-C 20?-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6048895-A | ANTAGONISTS OF PROSTAGLANDIN F FOR TREATING BONE FRACTURES AND DISEASES AND GLAUCOMA | THE PROCTER & GAMBLE COMPANY (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1999012898-A1 | AROMATIC C16-C20-SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-18 | — | — | WO | disclosed |