Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 11/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 11/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7616018 | 0.85 | PPARA (0.55) | PPARGPOLBLMNAPPARAPPARD | |
| SCHEMBL1618680 | 0.84 | PPARG (0.44) | PPARGPPARAPPARDMAPTKDM4E | |
| SCHEMBL7167664 | 0.83 | POLB (0.41) | POLBLMNACYP2C19CYP1A2BTN3A1 | |
| SCHEMBL11516039 | 0.81 | PPARA (0.51) | PPARGPOLBLMNAPPARAPPARD | |
| Lithium Ion SCHEMBL9303151 | 0.81 | PPARG (0.43) | PPARGPPARAPPARDMAPTKDM4E | |
| SCHEMBL7167780 | 0.79 | PPARG (0.41) | PPARGPOLBLMNAPPARAPPARD | |
| SCHEMBL10547306 | 0.78 | ALDH1A1 (0.41) | PPARGPOLBPPARAPPARDMAPT | |
| SCHEMBL6672222 | 0.78 | MAPT (0.46) | POLBLMNAMAPTKDM4ECYP2C19 | |
| SCHEMBL7695204 | 0.76 | PPARA (0.57) | PPARAMEN1KMT2A | |
| SCHEMBL11383504 | 0.76 | PPARG (0.46) | PPARGPOLBPPARAPPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401768-A | Prostaglandin derivative, antiulcer, hypotensive, anticoagulant | TORAY INDUSTRIES, INC. (JP) | 1995-03-28 | — | — | US | disclosed |
| EP-0365678-B1 | 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF | TORAY INDUSTRIES (JP) | 1994-01-05 | — | — | EP | disclosed |
| EP-0232776-B1 | 2,5,6,7-TETRANOR-4,8-INTER-M-PHENYLENE PGI2 DERIVATIVES | TORAY INDUSTRIES, INC. (JP) | 1990-10-24 | — | — | EP | disclosed |
| EP-0365678-A1 | 2,5,6,7-TETRANOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1990-05-02 | — | — | EP | disclosed |
| US-4822804-A | 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI2 derivatives and anti-ulcer, anti-thrombotic and anti-hypertensive pharmaceutical compositions containing them | TORAY INDUSTRIES, INC. (JP) | 1989-04-18 | — | — | US | disclosed |
| US-4775692-A | ANTILIPEMIC, ANTICOAGULANT, HYPOTENSIVE, ANTISECRETORY AND ANTIULCER AGENT | TORAY INDUSTRIES, INC. (JP) | 1988-10-04 | — | — | US | disclosed |
| EP-0273216-A2 | Prostacyclin analogue and anti-ulcer composition containing it as active ingredient | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1988-07-06 | — | — | EP | disclosed |
| EP-0232776-A2 | 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives | TORAY INDUSTRIES, INC. (JP) | 1987-08-19 | — | — | EP | disclosed |
| US-4304907-A | Bicyclo lactone intermediates for prostaglandin analogs | THE UPJOHN COMPANY (US) | 1981-12-08 | — | — | US | disclosed |
| US-4303796-A | 16-Phenoxy prostaglandin F2α analogs | THE UPJOHN COMPANY (US) | 1981-12-01 | — | — | US | disclosed |
| US-4154950-A | PROSTAGLANDIN, WOUND HEALING AGENTS, OXYTOCICS, ANTIULCER AGENTS, ANTICOAGULANT, DECONGESTANT | THE UPJOHN COMPANY (US) | 1979-05-15 | — | — | US | disclosed |
| US-4116988-A | 16-Phenoxy prostaglandin E1 analogs | THE UPJOHN COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4116989-A | 16-Phenoxy prostaglandin F1α analogs | THE UPJOHN COMPANY (US) | 1978-09-26 | — | — | US | disclosed |
| US-4087616-A | 16-Phenoxy prostaglandin A2 analogs | THE UPJOHN COMPANY (US) | 1978-05-02 | — | — | US | disclosed |
| US-4001300-A | ANTIULCER, DECONGESTANT, LABOR INDUCER, WOUND HEALER | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |