Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461201 | 0.86 | ALDH1A1 (0.41) | ALDH1A1TSHRKMT2A | |
| SCHEMBL1146257 | 0.84 | CHRM2 (0.48) | CHRM2ALDH1A1TSHRMAPTL3MBTL1 | |
| SCHEMBL514068 | 0.78 | HTT (0.33) | CHRM2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL10835425 | 0.72 | ALDH1A1 (0.42) | ALDH1A1TSHRKMT2A | |
| SCHEMBL16511614 | 0.69 | ALDH1A1 (0.37) | ALDH1A1TSHR | |
| SCHEMBL7621965 | 0.69 | CHRM2 (0.46) | CHRM2ALDH1A1MAPTL3MBTL1LMNA | |
| SCHEMBL14375981 | 0.68 | GABRA1 (0.41) | ALDH1A1TSHRMAPTL3MBTL1 | |
| SCHEMBL7086960 | 0.67 | APOBEC3G (0.58) | CHRM2ALDH1A1TSHRMAPTL3MBTL1 | |
| SCHEMBL7648830 | 0.67 | ALDH1A1 (0.40) | ALDH1A1TSHRL3MBTL1KMT2A | |
| SCHEMBL5250559 | 0.67 | SLC6A4 (0.42) | ALDH1A1TSHRLMNASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432988-B1 | RHEUMATIC DISEASES, (OSTEO)ARTHRITIS, CACHEXIA, INFLAMMATORY BOWEL DISEASE, TOXIC SHOCK SYNDROME, SEPSIS, CROHN*S DISEASE, PSORIASIS AND GOUT TREATMENT | MERCKLE GMBH (DE) | 2002-08-13 | — | — | US | disclosed |