SCHEMBL7616342

SCHEMBL7616342

O=C(c1c(Cl)cccc1Cl)P(=O)(Cc1ccccc1)C(=O)c1c(Cl)cccc1Cl

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.43
ALDH1A1 P00352 2/20 0.42
FEN1 P39748 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MAPT P10636 1/20 0.41
PTK2B Q14289 1/20 0.41
SCN5A Q14524 1/20 0.41
SCN2A Q99250 1/20 0.41
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
TRPM8 Q7Z2W7 1/20 0.40
AKR1B1 P15121 1/20 0.39
TXNRD1 Q16881 1/20 0.39
P2RX7 Q99572 1/20 0.39
POLB P06746 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7618248 0.86 HPGD (0.43) HPGDALDH1A1FEN1SMN1; SMN2MAPT
SCHEMBL9483135 0.83 NPC1 (0.45) ALDH1A1FEN1MAPTPTK2BSCN5A
SCHEMBL4264438 0.83 GAA (0.43) ALDH1A1SMN1; SMN2MAPTRAB9ANPC1
SCHEMBL7189050 0.82 NPSR1 (0.41) HPGDALDH1A1FEN1SMN1; SMN2MAPT
SCHEMBL7627882 0.79 L3MBTL1 (0.48) HPGDSMN1; SMN2P2RX7POLB
SCHEMBL6436912 0.77 NPC1 (0.45) ALDH1A1FEN1MAPTPTK2BSCN5A
SCHEMBL29933904 0.77 ALDH1A1 (0.47) HPGDALDH1A1FEN1SMN1; SMN2MAPT
SCHEMBL9483049 0.76 CETP (0.42) HPGDSCN5ASCN2A
SCHEMBL9484055 0.76 TAS1R3 (0.40) HPGDALDH1A1SMN1; SMN2RAB9ANPC1
SCHEMBL442209 0.76 TAAR1 (0.55) HPGDALDH1A1SMN1; SMN2RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6486228-B2 BIS-ACYLPHOSPHINE OXIDES AND ACYLPHOSPHINE OXIDES FOR CURING PHOTOPOLYMERIZABLE COMPOSITIONS WITHOUT YELLOWING; USE IN WHITE SURFACE COATINGS, AS NEGATIVE PHOTORESISTS, IN PRINTING PLATES CIBA SPECIALTY CHEMICALS CORPORATION 2002-11-26 US disclosed
US-20010036978-A1 Photoinitiator combinations IGM GROUP B.V. (NL) 2001-11-01 US disclosed
US-6251963-B1 ORGAOPHOSPHOROUS COMPOUND CONTAINING KETONE GROUP CIBA SPECIALTY CHEMICALS CORPORATION 2001-06-26 US disclosed
US-5218009-A Photoinitiators for the photopolymerization of ethylenically unsaturated compounds CIBA-GEIGY CORPORATION (US) 1993-06-08 US disclosed