Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | OXTR | P30559 | 7/20 | 0.39 |
| ▸ | AVPR1A | P37288 | 6/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7616585 | 1.00 | OPRM1 (0.41) | OPRM1OPRL1CHRNB2CHRNA4MCHR1 | |
| Bromide SCHEMBL7880295 | 0.79 | MEN1 (0.43) | MEN1KMT2AROCK2 | |
| Bromide SCHEMBL7880298 | 0.79 | MEN1 (0.43) | MEN1KMT2AROCK2 | |
| Bromide SCHEMBL8563694 | 0.78 | MAPT (0.49) | OPRM1MCHR1KMT2AROCK2 | |
| Bromide SCHEMBL8897811 | 0.78 | MAPT (0.49) | OPRM1MCHR1KMT2AROCK2 | |
| Bromide SCHEMBL7625301 | 0.77 | L3MBTL1 (0.43) | OPRM1GRM4ROCK2 | |
| Bromide SCHEMBL7625296 | 0.77 | L3MBTL1 (0.43) | OPRM1GRM4ROCK2 | |
| Bromide SCHEMBL8565603 | 0.76 | ATM (0.51) | OPRM1MEN1KMT2A | |
| Bromide SCHEMBL8897674 | 0.76 | ATM (0.51) | OPRM1MEN1KMT2A | |
| SCHEMBL7614154 | 0.75 | CHRNB2 (0.45) | OPRM1OPRL1CHRNB2CHRNA4MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620225-B1 | Cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| US-5523400-A | 3-(PYRROLIDIN-3-YLIDENE=CH-),7-((2-AMINOTHIAZOL-4-YL)HYDROX -IMINOACETYLAMINO-)-3-CEPHEM DERIVATIVES; BROAD SPECTRUM ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0620225-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-10-19 | — | — | EP | disclosed |