Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Triaziquone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 2/20 | 0.32 |
| ▸ | NSD2 | O96028 | 2/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GALK1 | P51570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triaziquone SCHEMBL1961248 | 0.98 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL11791565 | 0.92 | DNMT1 (0.39) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL5800741 | 0.91 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL11416072 | 0.90 | DNMT1 (0.40) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL610295 | 0.90 | DNMT1 (0.42) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL2160619 | 0.88 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL10379983 | 0.88 | DNMT1 (0.41) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL600168 | 0.86 | DNMT1 (0.40) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL5054475 | 0.86 | DNMT1 (0.47) | DNMT1TP53MAPTSTAT3HTT | |
| Triaziquone SCHEMBL7738777 | 0.86 | DNMT1 (0.47) | DNMT1TP53MAPTSTAT3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020177555-A1 | Precementum- and / or cementum - derived chemotactic factor (CCTF) of tooth of mammalia, process for purifying the same, and drug for accelerating adhesion of new connective tissue, comprising the same as active ingredient | KANEBO, LTD. | 2002-11-28 | — | — | US | claimed |
| US-6429193-B1 | ELUTION AND PURIFICATION OF GINGIVAL FIBROBLAST CHEMOTACTIC FACTOR (CCTF) FROM BOVINE SOURCE; USED TO ACCELERATE ADHESION OF NEW CONNECTIVE TISSUE BETWEEN TOOTH AND GUM AFTER PERIODONTAL SURGERY | KANEBO, LTD. (JP) | 2002-08-06 | — | — | US | claimed |
| EP-1008604-A1 | CELL CHEMOTACTIC FACTOR (CCTF) ORIGINATING IN MAMMALIAN TOOTH PRECEMENT OR CEMENT, METHOD FOR PURIFYING THE SAME, AND NOVEL CONNECTIVE TISSUE ADHESION PROMOTERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | KANEBO LTD. (JP) | 2000-06-14 | — | — | EP | claimed |
| WO-2011162562-A2 | [6+5] FUSED BICYCLES AS A THROMBIN ANTAGONIST, PROCESS FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE BICYCLES | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2011-12-29 | — | — | WO | disclosed |
| US-20020177555-A1 | Precementum- and / or cementum - derived chemotactic factor (CCTF) of tooth of mammalia, process for purifying the same, and drug for accelerating adhesion of new connective tissue, comprising the same as active ingredient | KANEBO, LTD. | 2002-11-28 | — | — | US | disclosed |
| US-6429193-B1 | ELUTION AND PURIFICATION OF GINGIVAL FIBROBLAST CHEMOTACTIC FACTOR (CCTF) FROM BOVINE SOURCE; USED TO ACCELERATE ADHESION OF NEW CONNECTIVE TISSUE BETWEEN TOOTH AND GUM AFTER PERIODONTAL SURGERY | KANEBO, LTD. (JP) | 2002-08-06 | — | — | US | disclosed |
| EP-1008604-A1 | CELL CHEMOTACTIC FACTOR (CCTF) ORIGINATING IN MAMMALIAN TOOTH PRECEMENT OR CEMENT, METHOD FOR PURIFYING THE SAME, AND NOVEL CONNECTIVE TISSUE ADHESION PROMOTERS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | KANEBO LTD. (JP) | 2000-06-14 | — | — | EP | disclosed |