Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | MTTP | P55157 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6675771 | 0.90 | SIGMAR1 (0.45) | SIGMAR1DRD3MTTPCHRM2ADRA2A | |
| SCHEMBL7638227 | 0.90 | SIGMAR1 (0.44) | SIGMAR1DRD3MTTPCHRM2ADRA2A | |
| SCHEMBL7611306 | 0.89 | ADRA1A (0.42) | SIGMAR1HTR2ADRD3HTR1ADRD2 | |
| SCHEMBL7607768 | 0.89 | MTTP (0.43) | SIGMAR1DRD3MTTPCHRM2ADRA2A | |
| SCHEMBL6678861 | 0.89 | MTTP (0.50) | SIGMAR1DRD3HTR1ADRD2HTR7 | |
| SCHEMBL7052025 | 0.88 | MTTP (0.51) | GAADRD3MTTPCHRM2ADRA2A | |
| SCHEMBL7611938 | 0.87 | SIGMAR1 (0.46) | SIGMAR1 | |
| SCHEMBL7637370 | 0.87 | SIGMAR1 (0.42) | SIGMAR1DRD3MTTPCHRM2ADRA2A | |
| SCHEMBL7607799 | 0.86 | SIGMAR1 (0.54) | SIGMAR1DRD3MTTPCHRM2ADRA2A | |
| SCHEMBL7608430 | 0.85 | SIGMAR1 (0.43) | SIGMAR1DRD3MTTPCHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1259492-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001047899-A1 | SUBSTITUTED PIPERAZINE DERIVATIVES AS MTP INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |