Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7617345 | 0.90 | CA1 (0.47) | MAPTPOLBLMNARXFP1THRB | |
| SCHEMBL7612894 | 0.88 | CA1 (0.56) | CA1CA2 | |
| SCHEMBL7616962 | 0.85 | POLB (0.43) | MAPTPOLBLMNACA1CA2 | |
| SCHEMBL7614212 | 0.82 | POLB (0.41) | MAPTPOLBLMNACA1CA2 | |
| SCHEMBL7618641 | 0.79 | MEN1 (0.52) | MAPTPOLBLMNARXFP1TP53 | |
| SCHEMBL9273892 | 0.79 | RAB9A (0.48) | LMNATP53MEN1KMT2AKDM4E | |
| SCHEMBL7610904 | 0.79 | MAPT (0.40) | MAPTPOLBLMNACA1CA2 | |
| SCHEMBL7613159 | 0.78 | MEN1 (0.43) | MAPTPOLBLMNARXFP1CA1 | |
| SCHEMBL9203805 | 0.78 | L3MBTL1 (0.54) | POLBMEN1KMT2AKDM4EGAA | |
| SCHEMBL9200971 | 0.77 | MEN1 (0.43) | MAPTPOLBLMNARXFP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869785-B1 | 4-HYDROXYCOUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS | UPJOHN CO (US) | 2002-08-28 | — | — | EP | claimed |