Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233107 | 0.91 | CYP2D6 (0.43) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5233110 | 0.91 | CYP2D6 (0.43) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL1618300 | 0.76 | NR3C1 (0.48) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5265856 | 0.76 | CYP2D6 (0.44) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL5265862 | 0.76 | CYP2D6 (0.44) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL2237372 | 0.72 | NR3C1 (0.45) | NR3C1CYP2D6ALDH1A1KDM4EGAA | |
| SCHEMBL18280972 | 0.71 | CYP2D6 (0.46) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL18280973 | 0.71 | CYP2D6 (0.46) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL18297025 | 0.71 | CYP2D6 (0.46) | NR3C1CYP2D6ALDH1A1TSHRCYP3A4 | |
| SCHEMBL7380692 | 0.70 | SIGMAR1 (0.55) | CYP3A4MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6433171-B1 | FOR OSTEOPOROSIS AND/OR FRAILTY, CONGESTIVE HEART FAILURE, FRAILTY ASSOCIATED WITH AGING, OBESITY; ACCELERATING BONE FRACTURE REPAIR, ATTENUATING PROTEIN CATABOLIC RESPONSE AFTER A MAJOR OPERATION, REDUCING CACHEXIA AND PROTEIN LOSS | PFIZER INC. | 2002-08-13 | — | — | US | disclosed |