Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenquizone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | HTR2B | P41595 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CA9 | Q16790 | 4/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenquizone SCHEMBL309550 | 0.85 | HSD17B10 (0.58) | CA2LMNACA1SMN1; SMN2PMP22 | |
| Fenquizone SCHEMBL29387757 | 0.85 | HSD17B10 (0.58) | CA2LMNACA1SMN1; SMN2PMP22 | |
| Hydrochlorothiazide SCHEMBL27674482 | 0.81 | LMNA (0.97) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL29366243 | 0.79 | LMNA (1.00) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL9349 | 0.79 | LMNA (1.00) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL156490 | 0.79 | LMNA (1.00) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL1333333 | 0.78 | LMNA (0.97) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10408471 | 0.78 | LMNA (0.97) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL9508286 | 0.78 | LMNA (0.97) | CA2LMNACA1CYP2C9SMN1; SMN2 | |
| Hydrochlorothiazide SCHEMBL10778059 | 0.78 | LMNA (0.97) | CA2LMNACA1CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235561-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | Panacea Biotec Limited (IN) | 2002-09-04 | — | — | EP | disclosed |
| WO-2001039749-A2 | FAST DISSOLVING COMPOSITION WITH PROLONGED SWEET TASTE | PANACEA BIOTEC LIMITED (IN) | 2001-06-07 | — | — | WO | disclosed |