Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 4/20 | 0.89 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.89 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.89 |
| ▸ | CBS | P35520 | 4/20 | 0.72 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.57 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.57 |
| ▸ | BACE1 | P56817 | 2/20 | 0.56 |
| ▸ | KLK1 | P06870 | 1/20 | 0.54 |
| ▸ | KLK3 | P07288 | 1/20 | 0.54 |
| ▸ | KLK2 | P20151 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | KLK6 | Q92876 | 1/20 | 0.54 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.52 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Volkensiflavone SCHEMBL27160551 | 1.00 | PRSS1 (0.89) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| Volkensiflavone SCHEMBL13829450 | 1.00 | PRSS1 (0.89) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| SCHEMBL27165462 | 0.94 | PRSS1 (0.90) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| Morelloflavone SCHEMBL615093 | 0.94 | PRSS1 (1.00) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| Morelloflavone SCHEMBL2383075 | 0.94 | PRSS1 (1.00) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| Pancibiflavonol SCHEMBL13829454 | 0.82 | PRSS1 (0.76) | PRSS1PRSS2PRSS3CBSPTPN1 | |
| SCHEMBL30209479 | 0.81 | PRSS1 (0.62) | PRSS1PRSS2PRSS3CBSCYP1A2 | |
| SCHEMBL6360019 | 0.74 | KLK1 (0.66) | PRSS1PRSS2PRSS3CBSKLK1 | |
| SCHEMBL28770111 | 0.74 | KLK1 (0.66) | PRSS1PRSS2PRSS3CBSKLK1 | |
| SCHEMBL6363033 | 0.74 | KLK1 (0.66) | PRSS1PRSS2PRSS3CBSKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1245230-A2 | Amentoflavone as an antiviral agent | Advanced Life Sciences Inc. (US) | 2002-10-02 | — | — | EP | disclosed |
| US-20020068757-A1 | Biflavanoids and derivatives thereof as antiviral agents | ADVANCED LIFE SCIENCES, INC. | 2002-06-06 | — | — | US | disclosed |
| US-6399654-B1 | ADMINISTERING MIXTURE OF VIRICIDE AND BIOFLAVANOID | ADVANCED LIFE SCIENCES, INC. | 2002-06-04 | — | — | US | disclosed |
| US-5948918-A | PLANT EXTRACTS | MEDICHEM RESEARCH, INC. (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998046238-A1 | BIFLAVINOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS, ALONE OR IN COMBINATION WITH AT LEAST ONE KNOWN ANTIVIRAL AGENT | MEDICHEM RESEARCH, INC. (US) | 1998-10-22 | — | — | WO | disclosed |
| US-5773462-A | INFLUENZA THERAPY | MEDICHEM RESEARCH, INC. (US) | 1998-06-30 | — | — | US | disclosed |
| EP-0833631-A1 | BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | MEDICHEM RESEARCH, INC. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1997000679-A1 | BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS | MEDICHEM RESEARCH, INC. (US) | 1997-01-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020068757-A1 | Biflavanoids and derivatives thereof as antiviral agents | HK2, GYS2, HK1 | PRSS1 2331/4885PRSS2 1604/4885PRSS3 2085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.