Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6402426 | 0.85 | ADRB1 (0.45) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL7613434 | 0.84 | OPRM1 (0.43) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL7618934 | 0.82 | HIF1A (0.36) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL6397993 | 0.82 | HIF1A (0.40) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL7621421 | 0.80 | HIF1A (0.37) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL6396452 | 0.79 | OPRM1 (0.45) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL7618317 | 0.79 | ADRB1 (0.41) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL6396095 | 0.77 | MAPT (0.43) | ADRB1ADRA1AMIFHTR2AHTR2B | |
| SCHEMBL7622196 | 0.77 | TYR (0.41) | TYRADRB1ADRA1AMIFHTR2A | |
| SCHEMBL6396467 | 0.77 | ADRB1 (0.39) | ADRB1ADRA1AMIFHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1175425-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000043402-A2 | INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2000-07-27 | — | — | WO | disclosed |