Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602954 | 0.96 | SIGMAR1 (0.33) | SIGMAR1CHRM5CHRM3KDM1A | |
| SCHEMBL7623470 | 0.77 | SIGMAR1 (0.36) | SIGMAR1CHRM5CHRM3KDM1A | |
| SCHEMBL7628942 | 0.76 | SIGMAR1 (0.35) | SIGMAR1CHRM5CHRM3KDM1A | |
| SCHEMBL1982449 | 0.75 | — | — | |
| SCHEMBL6603001 | 0.74 | OPRM1 (0.47) | SIGMAR1 | |
| SCHEMBL7618792 | 0.74 | SIGMAR1 (0.32) | SIGMAR1CHRM5CHRM3 | |
| SCHEMBL22034009 | 0.73 | MEN1 (0.41) | SIGMAR1CHRM5CHRM3 | |
| SCHEMBL2956414 | 0.72 | SIGMAR1 (0.40) | SIGMAR1CHRM5CHRM3 | |
| SCHEMBL1964999 | 0.71 | USP2 (0.32) | — | |
| SCHEMBL7625027 | 0.71 | SIGMAR1 (0.36) | SIGMAR1CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | IKEDA TAKAFUMI (JP) | 2001-11-29 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, CNR2 | SIGMAR1 127/4885CHRM5 337/4885CHRM3 417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.