Sugi Predict

Sugi Predict / Compounds / SCHEMBL762129

SCHEMBL762129

SCHEMBL762129

c1ccc(-c2c3c(c(-c4ccccc4)c4ccccc24)-c2ccc(-c4c5ccccc5c5c6c(cccc46)-c4c(-c6ccccn6)ccc(-c6ccccn6)c4-5)c4cccc-3c24)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRD4 O60885 1/20 0.35
▸ GRM5 P41594 2/20 0.34
▸ TGFBR1 P36897 2/20 0.34
▸ SMN1; SMN2 Q16637 4/20 0.33
▸ HPGD P15428 3/20 0.33
▸ MAPK1 P28482 3/20 0.33
▸ KDM4E B2RXH2 3/20 0.33
▸ NPC1 O15118 3/20 0.33
▸ TP53 P04637 3/20 0.33
▸ HSD17B10 Q99714 2/20 0.33
▸ PRKCI P41743 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ LMNA P02545 4/20 0.33
▸ RAB9A P51151 2/20 0.33
▸ TSHR P16473 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CASP3 P42574 1/20 0.33
▸ SENP8 Q96LD8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10021054 0.88 KDM4E (0.38) BRD4GRM5TGFBR1SMN1; SMN2HPGD
SCHEMBL12032294 0.82 LMNA (0.42) BRD4TGFBR1SMN1; SMN2HPGDMAPK1
SCHEMBL11992079 0.82 SMN1; SMN2 (0.49) TGFBR1SMN1; SMN2HPGDMAPK1KDM4E
SCHEMBL11992293 0.82 KDM4E (0.49) GRM5TGFBR1SMN1; SMN2HPGDMAPK1
SCHEMBL12032316 0.82 PRKDC (0.39) GRM5TGFBR1SMN1; SMN2HPGDMAPK1
SCHEMBL762142 0.81 CRHBP (0.37) BRD4TGFBR1SMN1; SMN2HPGDMAPK1
SCHEMBL12269907 0.81 PDK2 (0.36) BRD4GRM5TGFBR1SMN1; SMN2HPGD
SCHEMBL15178249 0.81 KDM4E (0.47) GRM5TGFBR1SMN1; SMN2HPGDMAPK1
SCHEMBL11992078 0.81 SMN1; SMN2 (0.47) TGFBR1SMN1; SMN2HPGDMAPK1KDM4E
SCHEMBL11992267 0.81 TGFBR1 (0.40) TGFBR1SMN1; SMN2HPGDMAPK1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8138668-B2 Benzo[a]fluoranthene compound and organic light emitting device using the same CANON KABUSHIKI KAISHA (JP) 2012-03-20 — — US disclosed
US-8138668-B2 Benzo[a]fluoranthene compound and organic light emitting device using the same CANON KABUSHIKI KAISHA (JP) 2012-03-20 — — US disclosed
US-20100019661-A1 BENZO[a]FLUORANTHENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME CANON KABUSHIKI KAISHA (JP) 2010-01-28 — — US disclosed
US-20100019661-A1 BENZO[a]FLUORANTHENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME CANON KABUSHIKI KAISHA (JP) 2010-01-28 — — US disclosed
WO-2008140134-A1 BENZO[A]FLUORANTHENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME CANON KABUSHIKI KAISHA (JP) 2008-11-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100019661-A1 BENZO[a]FLUORANTHENE COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME AFF1, AFF2, CYP1A1 BRD4 599/4885GRM5 1709/4885TGFBR1 1071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.