Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7621505 | 1.00 | CRBN (0.43) | CRBNPOLBALDH1A1MAPTHTT | |
| Bromide SCHEMBL8564796 | 0.86 | ALDH1A1 (0.36) | CRBNPOLBALDH1A1MAPTHTT | |
| Bromide SCHEMBL8564801 | 0.86 | ALDH1A1 (0.36) | CRBNPOLBALDH1A1MAPTHTT | |
| Bromide SCHEMBL7880295 | 0.80 | MEN1 (0.43) | CRBNPOLBNPC1RAB9A | |
| Bromide SCHEMBL7880298 | 0.80 | MEN1 (0.43) | CRBNPOLBNPC1RAB9A | |
| Bromide SCHEMBL8897946 | 0.80 | GAA (0.35) | ALDH1A1SMN1; SMN2LMNAGAA | |
| Bromide SCHEMBL8562114 | 0.80 | GAA (0.35) | ALDH1A1SMN1; SMN2LMNAGAA | |
| Bromide SCHEMBL9076744 | 0.80 | MEN1 (0.40) | CRBNALDH1A1MAPTLMNASIGMAR1 | |
| Bromide SCHEMBL9076742 | 0.80 | MEN1 (0.40) | CRBNALDH1A1MAPTLMNASIGMAR1 | |
| Bromide SCHEMBL7614674 | 0.79 | L3MBTL1 (0.46) | POLBALDH1A1MAPTL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620225-B1 | Cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-11-13 | — | — | EP | disclosed |
| EP-0879237-A1 | ISOOXACEPHEM DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-11-25 | — | — | EP | disclosed |
| US-5811419-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-22 | — | — | US | disclosed |
| WO-1997026260-A1 | ISOOXACEPHEM DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-07-24 | — | — | WO | disclosed |
| US-5523400-A | 3-(PYRROLIDIN-3-YLIDENE=CH-),7-((2-AMINOTHIAZOL-4-YL)HYDROX -IMINOACETYLAMINO-)-3-CEPHEM DERIVATIVES; BROAD SPECTRUM ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0620225-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1994-10-19 | — | — | EP | disclosed |