Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8562114 | 1.00 | GAA (0.35) | GAAALDH1A1SMN1; SMN2FAAHP2RX7 | |
| Bromide SCHEMBL8564801 | 0.82 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2KMT2ALMNATSHR | |
| Bromide SCHEMBL8564796 | 0.82 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2KMT2ALMNATSHR | |
| Bromide SCHEMBL7621505 | 0.80 | CRBN (0.43) | GAAALDH1A1SMN1; SMN2LMNA | |
| Bromide SCHEMBL7621499 | 0.80 | CRBN (0.43) | GAAALDH1A1SMN1; SMN2LMNA | |
| Bromide SCHEMBL8560291 | 0.78 | KMT2A (0.45) | MEN1KMT2AFPR2LMNA | |
| Bromide SCHEMBL8898107 | 0.78 | KMT2A (0.45) | MEN1KMT2AFPR2LMNA | |
| Bromide SCHEMBL8560897 | 0.76 | ALDH1A1 (0.40) | ALDH1A1P2RX7MEN1KMT2ALMNA | |
| Bromide SCHEMBL8897674 | 0.76 | ATM (0.51) | GAAALDH1A1MEN1KMT2AGFER | |
| Bromide SCHEMBL8560903 | 0.76 | ALDH1A1 (0.40) | ALDH1A1P2RX7MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |