Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1279836 | 0.86 | ALDH1A1 (0.58) | ALDH1A1CYP1A1CYP1B1CYP19A1CYP3A4 | |
| SCHEMBL20865065 | 0.86 | ALDH1A1 (0.50) | ALDH1A1CYP1A1CYP1B1CYP19A1CYP3A4 | |
| SCHEMBL11261073 | 0.84 | ALDH1A1 (0.55) | ALDH1A1CYP1A1CYP1B1CYP19A1CYP3A4 | |
| SCHEMBL2618040 | 0.83 | DAO (0.44) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL10175240 | 0.80 | TACR1 (0.45) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL418489 | 0.78 | TACR1 (0.47) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL3933079 | 0.78 | TACR1 (0.44) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL1936578 | 0.78 | TACR1 (0.44) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL10204849 | 0.78 | TACR1 (0.51) | TACR1ALDH1A1ACHECYP1A1CYP1B1 | |
| SCHEMBL586588 | 0.78 | MARS1 (0.42) | ALDH1A1CYP19A1GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440989-B2 | ANTITUMOR AGENT | SCHERING CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-20010016585-A1 | Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase | AFONSO ADRIANO (IN) | 2001-08-23 | — | — | US | disclosed |
| US-6218401-B1 | FOR THERAPY OF PANCREATIC TUMOR CELLS, LUNG CANCER CELLS, MYELOID LEUKEMIA TUMOR CELLS, THYROID FOLLICULAR TUMOR CELLS, MYELODYSPLASTIC TUMOR CELLS, EPIDERMAL CARCINOMA TUMOR CELLS, BLADDER CARCINOMA TUMOR CELLS OR PROSTATE TUMOR CELLS | SCHERING CORPORATION | 2001-04-17 | — | — | US | disclosed |
| CN-1267292-A | Phenyl-substd. tricyclic inhibitors of farnesyl-protein transferase | SCHERING CORP (US) | 2000-09-20 | — | — | CN | disclosed |
| EP-0989981-A1 | NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998057950-A1 | NOVEL PHENYL-SUBSTITUTED TRICYCLIC INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |
| US-4058642-A | HYPERTENSIVE | BOEHRINGER INGELHEIM GMBH (DT) | 1977-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010016585-A1 | Novel phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase | FNTA, FNTB, HRAS | TACR1 4030/4885ALDH1A1 3245/4885ACHE 3214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.