Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.60 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.60 |
| ▸ | GPR4 | P46093 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972057 | 0.92 | AGTR1 (0.71) | AGTR1AGTR2LMNA | |
| SCHEMBL29486817 | 0.91 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL7622112 | 0.91 | AGTR1 (0.72) | AGTR1AGTR2 | |
| SCHEMBL9312828 | 0.90 | AGTR1 (0.68) | AGTR1AGTR2 | |
| Hydrochloric Acid SCHEMBL7841670 | 0.90 | AGTR1 (0.71) | AGTR1AGTR2 | |
| SCHEMBL9851478 | 0.88 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL8876431 | 0.88 | AGTR1 (0.53) | AGTR1AGTR2GPR4LMNATP53 | |
| SCHEMBL9854370 | 0.86 | AGTR1 (0.51) | AGTR1AGTR2LMNATP53 | |
| SCHEMBL9851500 | 0.85 | AGTR1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9854484 | 0.85 | AGTR1 (0.49) | AGTR1AGTR2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | claimed |
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| EP-0434038-A1 | Fused imidazole derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-06-26 | — | — | EP | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |