Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7622303 | 1.00 | GLS (0.41) | GLSHTTATMPOLBMALT1 | |
| SCHEMBL7643594 | 0.82 | KMT2A (0.45) | KMT2A | |
| SCHEMBL7774834 | 0.82 | HPGD (0.41) | POLBKMT2A | |
| SCHEMBL7643596 | 0.82 | KMT2A (0.45) | KMT2A | |
| SCHEMBL7645866 | 0.82 | KMT2A (0.45) | KMT2A | |
| SCHEMBL3217867 | 0.81 | CTSC (0.42) | POLB | |
| Bromide SCHEMBL9551371 | 0.81 | KMT2A (0.44) | KMT2A | |
| SCHEMBL7622435 | 0.81 | CTSC (0.42) | POLB | |
| SCHEMBL4986522 | 0.80 | HTT (0.56) | HTTATMCNR1NPY1RKMT2A | |
| SCHEMBL1363687 | 0.80 | CTSS (0.37) | HTTATMPOLBNPY1RKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448282-B1 | H3 HISTAMINE RECEPTOR ANTAGONIST ACTIVITY; ALLERGY, INFLAMMATION, CARDIOVASCULAR DISEASE, DEPRESSION, SCHIZOPHRENIA, NARCOLEPSY, SLEEP APNEA, INSOMNIA, EPILEPSY, HYPOTHALAMIC DYSFUNCTION | GLIATECH, INC. | 2002-09-10 | — | — | US | disclosed |
| US-6166060-A | 1H-4(5)-substituted imidazole derivatives | GLIATECH, INC. (US) | 2000-12-26 | — | — | US | disclosed |