Sugi Predict

Sugi Predict / Compounds / Fluphenazine

Fluphenazine

Fluphenazine

SCHEMBL7623667

CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2.Cl.Cl.Cl.Cl.O=C(O)/C=C\C(=O)O.O=C(O)/C=C\C(=O)O.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1.OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DRD2

The experimentally established mechanism targets of Fluphenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ DRD2 known ✓ P14416 4/20 0.74
▸ LMNA P02545 6/20 0.74
▸ MAPT P10636 6/20 0.74
▸ SMN1; SMN2 Q16637 5/20 0.74
▸ USP2 O75604 5/20 0.74
▸ CYP3A4 P08684 4/20 0.74
▸ MAPK1 P28482 4/20 0.74
▸ NPSR1 Q6W5P4 4/20 0.74
▸ HTR1A P08908 4/20 0.74
▸ ADRA2B P18089 4/20 0.74
▸ ADRA2C P18825 4/20 0.74
▸ SLC6A2 P23975 4/20 0.74
▸ HTR2A P28223 4/20 0.74
▸ SLC6A4 P31645 4/20 0.74
▸ ADRA1A P35348 4/20 0.74
▸ HRH1 P35367 4/20 0.74
▸ DRD3 P35462 4/20 0.74
▸ HTR2B P41595 4/20 0.74
▸ SLC6A3 Q01959 4/20 0.74
▸ KCNH2 Q12809 4/20 0.74

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetophenazine SCHEMBL2448563 0.98 LMNA (0.71) LMNAMAPTSMN1; SMN2USP2CYP3A4
Fluphenazine SCHEMBL565707 0.93 LMNA (0.85) LMNAMAPTSMN1; SMN2USP2CYP3A4
Fluphenazine SCHEMBL565708 0.93 LMNA (0.85) LMNAMAPTSMN1; SMN2USP2CYP3A4
Acetophenazine SCHEMBL28843774 0.92 HTR1A (0.79) LMNAMAPTSMN1; SMN2USP2CYP3A4
Acetophenazine SCHEMBL123792 0.92 HRH1 (0.89) LMNAMAPTSMN1; SMN2USP2CYP3A4
Acetophenazine SCHEMBL123789 0.92 HRH1 (0.89) LMNAMAPTSMN1; SMN2USP2CYP3A4
Acetophenazine SCHEMBL1155759 0.92 HRH1 (0.89) LMNAMAPTSMN1; SMN2USP2CYP3A4
Acetophenazine SCHEMBL30903895 0.92 HRH1 (0.89) LMNAMAPTSMN1; SMN2USP2CYP3A4
Fluphenazine SCHEMBL27704688 0.89 LMNA (0.88) LMNAMAPTSMN1; SMN2USP2CYP3A4
Trifluoperazine SCHEMBL1590789 0.87 RAD52 (0.84) LMNAMAPTSMN1; SMN2USP2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1139773-A4 CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING WRIGLEY W M JUN CO (US) 2002-06-12 — — EP disclosed
EP-1139773-A1 CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING WM. WRIGLEY JR. COMPANY (US) 2001-10-10 — — EP disclosed
WO-2000035295-A1 CONTROLLING RELEASE OF ACTIVE AGENTS FROM A CHEWING GUM COATING WM. WRIGLEY JR. COMPANY (US) 2000-06-22 — — WO disclosed