Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210135 | 1.00 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL3658524 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL2762810 | 0.83 | KDM4E (0.46) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL4553803 | 0.79 | KDM4E (0.44) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL3831520 | 0.73 | BCAT2 (0.46) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL731619 | 0.72 | IRAK4 (0.52) | KDM4EALDH1A1HPGDMAPTBCAT2 | |
| SCHEMBL105262 | 0.71 | IRAK4 (0.55) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL31632660 | 0.71 | IRAK4 (0.55) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL4431290 | 0.71 | KDM4E (0.47) | KDM4EALDH1A1HPGDMAPTBCAT2 | |
| Hydrochloric Acid SCHEMBL3683840 | 0.71 | IRAK4 (0.50) | KDM4EALDH1A1HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915076-B1 | Process for the preparation of trans-(R,R)-actinol | HOFFMANN LA ROCHE (CH) | 2002-01-16 | — | — | EP | claimed |
| US-6187961-B1 | HYDROGENATING (R)-LEVODIONE IN PRESENCE OF HYDROGEN DONAR AND A SOLVENT OR IN PRESENCE OF HYDROGEN DONOR WHICH SIMULTANEOUSLY USED AS THE SOLVENT, AND AN AMINO-AMIDE-RUTHENIUM COMPLEX | ROCHE VITAMINS INC. | 2001-02-13 | — | — | US | claimed |
| EP-0915076-A1 | Process for the preparation of trans-(R,R)-actinol | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | claimed |
| EP-0915076-B1 | Process for the preparation of trans-(R,R)-actinol | HOFFMANN LA ROCHE (CH) | 2002-01-16 | — | — | EP | disclosed |
| US-6300509-B1 | CATALYST FOR DIASTEREOSELECTIVE TRANSFER HYDROGENATION OF (R)-LEVODIONE TO TRANS-(R,R)-ACTINOL IN PRESENCE OF HYDROGEN DONOR, WHICH SIMULTANEOUSLY CAN BE USED AS SOLVENT | ROCHE VITAMINS INC. | 2001-10-09 | — | — | US | disclosed |
| US-6187961-B1 | HYDROGENATING (R)-LEVODIONE IN PRESENCE OF HYDROGEN DONAR AND A SOLVENT OR IN PRESENCE OF HYDROGEN DONOR WHICH SIMULTANEOUSLY USED AS THE SOLVENT, AND AN AMINO-AMIDE-RUTHENIUM COMPLEX | ROCHE VITAMINS INC. | 2001-02-13 | — | — | US | disclosed |
| EP-0915076-A1 | Process for the preparation of trans-(R,R)-actinol | F. HOFFMANN-LA ROCHE AG (CH) | 1999-05-12 | — | — | EP | disclosed |