Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 8/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762540 | 0.92 | HRH1 (0.39) | HRH1CYP2D6P2RX3POLBKCNH2 | |
| SCHEMBL762541 | 0.86 | HRH1 (0.38) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL762543 | 0.86 | CYP2D6 (0.36) | HRH1CYP2D6KCNH2TP53 | |
| SCHEMBL740554 | 0.84 | KCNH2 (0.39) | HRH1CYP2D6P2RX3KCNH2CHRM1 | |
| SCHEMBL740553 | 0.84 | KCNH2 (0.39) | HRH1CYP2D6P2RX3KCNH2CHRM1 | |
| SCHEMBL10292140 | 0.79 | PADI4 (0.37) | HRH1CYP2D6P2RX3KCNH2CHRM1 | |
| SCHEMBL762546 | 0.79 | KCNH2 (0.37) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL763431 | 0.78 | HRH1 (0.38) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL762831 | 0.78 | TLR8 (0.36) | HRH1CYP2D6KCNH2TP53 | |
| SCHEMBL763459 | 0.77 | KCNH2 (0.39) | HRH1CYP2D6KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |