Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | NPY1R | P25929 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739272 | 0.92 | NPY1R (0.36) | CYP2D6HRH1NPY1ROPRK1KCNH2 | |
| SCHEMBL739273 | 0.92 | NPY1R (0.36) | CYP2D6HRH1NPY1ROPRK1KCNH2 | |
| SCHEMBL762543 | 0.92 | CYP2D6 (0.36) | TLR8CYP2D6HRH1NPY1RNPC1 | |
| SCHEMBL763431 | 0.88 | HRH1 (0.38) | TLR8CYP2D6HRH1OPRD1OPRK1 | |
| SCHEMBL762540 | 0.87 | HRH1 (0.39) | TLR8CYP2D6HRH1PROKR1KCNH2 | |
| SCHEMBL738776 | 0.84 | CFD (0.38) | CYP2D6HRH1KCNH2TP53 | |
| SCHEMBL738775 | 0.84 | CFD (0.38) | CYP2D6HRH1KCNH2TP53 | |
| SCHEMBL762546 | 0.84 | KCNH2 (0.37) | CYP2D6HRH1NPY1RKCNH2 | |
| SCHEMBL739244 | 0.81 | HRH1 (0.46) | CYP2D6HRH1KCNH2 | |
| SCHEMBL739245 | 0.81 | HRH1 (0.46) | CYP2D6HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |