Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763431 | 0.92 | HRH1 (0.38) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL762543 | 0.88 | CYP2D6 (0.36) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL762535 | 0.86 | HRH1 (0.40) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| SCHEMBL740700 | 0.84 | KCNH2 (0.36) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL740699 | 0.84 | KCNH2 (0.36) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL762548 | 0.84 | KCNH2 (0.40) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL762546 | 0.80 | KCNH2 (0.37) | HRH1CYP2D6KCNH2CHRM1 | |
| SCHEMBL762831 | 0.80 | TLR8 (0.36) | HRH1CYP2D6NPC1RAB9AKCNH2 | |
| SCHEMBL742487 | 0.79 | HRH1 (0.36) | HRH1CYP2D6KCNH2PROKR1CHRM1 | |
| SCHEMBL763816 | 0.79 | CTSB (0.36) | HRH1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |