Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015793 | 0.96 | MAPT (0.48) | MAPTGAAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL27325815 | 0.95 | MAPT (0.47) | MAPTGAAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL3668560 | 0.90 | SMN1; SMN2 (0.46) | MAPTALDH1A1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL738515 | 0.89 | ALDH1A1 (0.48) | MAPTALDH1A1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL3668042 | 0.89 | SMN1; SMN2 (0.45) | MAPTALDH1A1L3MBTL1TDP1KMT2A | |
| SCHEMBL2087478 | 0.87 | KDM4E (0.54) | MAPTALDH1A1L3MBTL1KMT2ASMN1; SMN2 | |
| SCHEMBL14249239 | 0.87 | SMN1; SMN2 (0.49) | MAPTGAAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL23273490 | 0.86 | MEN1 (0.52) | MAPTGAAALDH1A1L3MBTL1KMT2A | |
| SCHEMBL11445418 | 0.83 | MAPT (0.69) | MAPTGAAALDH1A1L3MBTL1TDP1 | |
| SCHEMBL3478216 | 0.83 | MAPT (0.56) | MAPTGAAALDH1A1L3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |