Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6975153 | 0.88 | MEN1 (0.34) | MEN1KMT2ARIPK1ACE | |
| SCHEMBL6962545 | 0.86 | MEN1 (0.41) | MEN1KMT2ARIPK1ACE | |
| SCHEMBL6973366 | 0.82 | ACE (0.41) | ACE | |
| SCHEMBL6957854 | 0.81 | GHSR (0.38) | MEN1KMT2AACE | |
| SCHEMBL6973916 | 0.80 | TP53 (0.41) | ACE | |
| SCHEMBL3873900 | 0.80 | SIRT1 (0.40) | MEN1KMT2AACE | |
| SCHEMBL6961228 | 0.79 | MTNR1B (0.41) | ACE | |
| SCHEMBL6974443 | 0.79 | ACE (0.38) | MEN1KMT2AACE | |
| SCHEMBL6970287 | 0.78 | MTNR1B (0.42) | ACE | |
| SCHEMBL6967615 | 0.78 | MTNR1B (0.42) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181954-A2 | Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (ApoB) secretion | PFIZER INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-1996040640-A1 | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |