Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7627749 | 0.81 | MC4R (0.50) | KMT2AHTR1AHTR7ALDH1A1MC4R | |
| SCHEMBL6543308 | 0.79 | CYP2D6 (0.57) | CYP2D6ALDH1A1TSHR | |
| SCHEMBL1995314 | 0.79 | CYP2D6 (0.57) | CYP2D6ALDH1A1TSHRSIGMAR1OPRM1 | |
| Hydrochloric Acid SCHEMBL10644303 | 0.79 | TSHR (0.48) | CYP2D6KMT2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL5471103 | 0.78 | ALDH1A1 (0.42) | KMT2AALDH1A1HDAC1 | |
| SCHEMBL7620722 | 0.78 | SIGMAR1 (0.51) | CYP2D6KMT2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL1991966 | 0.76 | CYP2D6 (0.59) | CYP2D6ALDH1A1TSHRSIGMAR1HDAC4 | |
| SCHEMBL7631476 | 0.75 | TSHR (0.55) | CYP2D6KMT2AHTR1AHTR7ALDH1A1 | |
| SCHEMBL7628483 | 0.75 | MAPK1 (0.46) | CYP2D6KMT2AALDH1A1TSHRSIGMAR1 | |
| Hydrochloric Acid SCHEMBL8416135 | 0.75 | CYP2D6 (0.58) | CYP2D6KMT2AALDH1A1TSHRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444677-B2 | TREATMENT OF INFLAMMATION, CARDIOVASCULAR DISEASE, PAIN, ETC. | PFIZER INC. | 2002-09-03 | — | — | US | disclosed |
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | IKEDA TAKAFUMI (JP) | 2001-11-29 | — | — | US | disclosed |
| EP-1106614-A1 | 5-Membered heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | PFIZER INC. (US) | 2001-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046993-A1 | 5-memberd heteroaryl substituted 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, CNR2 | CYP2D6 716/4885KMT2A 3716/4885HTR1A 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.