SCHEMBL7628720

SCHEMBL7628720

C=Cc1ccc(COc2cc(COc3cc(CO)cc(OCc4cc(OCc5ccc(C=C)cc5)cc(OCc5ccc(C=C)cc5)c4)c3)cc(OCc3ccc(C=C)cc3)c2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.42
TSHR P16473 1/20 0.42
HIF1A Q16665 1/20 0.41
CYP1A1 P04798 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP19A1 P11511 1/20 0.40
FFAR1 O14842 1/20 0.39
PPARG P37231 1/20 0.39
PPARD Q03181 1/20 0.39
PPARA Q07869 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
CASP3 P42574 1/20 0.38
SENP8 Q96LD8 1/20 0.38
SENP7 Q9BQF6 1/20 0.38
SENP6 Q9GZR1 1/20 0.38
CYP4F2 P78329 1/20 0.37
CYP4A11 Q02928 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL439247 0.98 SMN1; SMN2 (0.43) SMN1; SMN2TSHRHIF1ACYP1A1CYP1A2
SCHEMBL6394555 0.88 ALDH1A1 (0.46) SMN1; SMN2HIF1ACYP1A1CYP1A2CYP19A1
SCHEMBL3241768 0.85 NPC1 (0.47) SMN1; SMN2HIF1ACYP1A2MEN1KMT2A
SCHEMBL7619064 0.82 HIF1A (0.40) SMN1; SMN2HIF1ACYP1A1CYP1A2CYP19A1
SCHEMBL2849503 0.81 CYP1A2 (0.41) SMN1; SMN2TSHRHIF1ACYP1A1CYP1A2
SCHEMBL18959614 0.80 RXRA (0.45) SMN1; SMN2HIF1ACYP1A1CYP1A2CYP19A1
SCHEMBL14341693 0.80 KMT2A (0.43) SMN1; SMN2TSHRHIF1AFFAR1PPARG
SCHEMBL6388039 0.79 APP (0.54) SMN1; SMN2RAB9ANPC1CASP3SENP8
SCHEMBL13242652 0.79 APP (0.54) SMN1; SMN2RAB9ANPC1CASP3SENP8
SCHEMBL7627169 0.78 MEN1 (0.67) SMN1; SMN2TSHRHIF1AFFAR1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6441112-B1 TADDOL and titanium ( ) taddolate dendrimers and composition NOVARTIS AG (CH) 2002-08-27 US disclosed
US-6211316-B1 Taddol and titanium (IV) taddolate dendrimers NOVARTIS AG (CH) 2001-04-03 US disclosed