Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MMP3 | P08254 | 1/20 | 0.32 |
| ▸ | MMP9 | P14780 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625426 | 0.85 | LMNA (0.36) | LMNATSHRMMP1CYP2D6ALDH1A1 | |
| SCHEMBL6680226 | 0.84 | TSHR (0.42) | LMNATSHRALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7623909 | 0.79 | CYP2D6 (0.41) | LMNATSHRCYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL16877152 | 0.78 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7628960 | 0.73 | TSHR (0.39) | LMNATSHRSMN1; SMN2MAPTEPHX2 | |
| SCHEMBL24242166 | 0.73 | LMNA (0.42) | LMNATSHRMMP1CYP2D6ALDH1A1 | |
| SCHEMBL1881180 | 0.73 | LMNA (0.42) | LMNATSHRMMP1CYP2D6ALDH1A1 | |
| SCHEMBL7233413 | 0.72 | TSHR (0.34) | TSHR | |
| SCHEMBL8468354 | 0.71 | TSHR (0.31) | TSHR | |
| SCHEMBL14073853 | 0.69 | MMP1 (0.48) | TSHRMMP1ALDH1A1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0847974-B1 | Process for the preparation of cyclopropylacetylene and its derivatives | KURARAY CO (JP) | 2002-06-05 | — | — | EP | disclosed |
| US-5955627-A | Process for the preparation of cyclopropylacetylene derivatives | KURARAY CO., LTD. (JP) | 1999-09-21 | — | — | US | disclosed |
| EP-0847974-A1 | Process for the preparation of cyclopropylacetylene and its derivatives | KURARAY CO., LTD. (JP) | 1998-06-17 | — | — | EP | disclosed |