Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6932566 | 1.00 | KMT2A (0.73) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL5100197 | 1.00 | KMT2A (0.73) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL5106479 | 0.86 | KMT2A (0.54) | KMT2ANPC1MEN1POLBL3MBTL1 | |
| SCHEMBL6014923 | 0.84 | KMT2A (0.75) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL29110220 | 0.83 | KMT2A (0.55) | KMT2ANPC1MEN1POLBTSHR | |
| SCHEMBL27006319 | 0.83 | L3MBTL1 (0.52) | KMT2ANPC1MEN1POLBTSHR | |
| SCHEMBL27130183 | 0.83 | L3MBTL1 (0.52) | KMT2ANPC1MEN1POLBTSHR | |
| SCHEMBL5097060 | 0.83 | L3MBTL1 (0.52) | KMT2ANPC1MEN1POLBTSHR | |
| SCHEMBL10830586 | 0.83 | KMT2A (0.73) | KMT2ANPC1MEN1POLBNPSR1 | |
| SCHEMBL2882513 | 0.82 | HDAC3 (0.56) | KMT2ANPC1MEN1L3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070042-A2 | PROCESS FOR THE PREPARATION OF HPB ESTERS | Ciba SC Holding AG (CH) | 2001-01-24 | — | — | EP | claimed |
| WO-1999050223-A2 | PROCESS FOR THE PREPARATION OF HPB ESTERS | CIBA SPECIALTY CHEMICALS HOLDING, INC. (CH) | 1999-10-07 | — | — | WO | claimed |
| EP-4313986-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | Genentech, Inc. (US) | 2024-02-07 | — | — | EP | disclosed |
| US-20240034739-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | GENENTECH, INC. (US) | 2024-02-01 | — | — | US | disclosed |
| CN-117098762-A | Process for preparing bicyclic ketone compounds | 基因泰克公司 | 2023-11-21 | — | — | CN | disclosed |
| WO-2022212809-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | GENENTECH, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| CN-103898072-B | A kind of Ketoreductase mutant and application thereof | HANGZHOU NORMAL UNIVERSITY (CN) | 2016-03-16 | — | — | CN | disclosed |
| CN-103898072-A | Ketoreductase mutant and application thereof | UNIV HANGZHOU NORMAL | 2014-07-02 | — | — | CN | disclosed |
| US-6417389-B1 | ENANTIOSELECTIVE HYDROGENATION USING PALLADIUM CATALYST AND CINCHONA ALKALOID CHIRAL MODIFIER | CIBA SPECIALTY CHEMICALS CORPORATION | 2002-07-09 | — | — | US | disclosed |
| EP-1070042-A2 | PROCESS FOR THE PREPARATION OF HPB ESTERS | Ciba SC Holding AG (CH) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999050223-A2 | PROCESS FOR THE PREPARATION OF HPB ESTERS | CIBA SPECIALTY CHEMICALS HOLDING, INC. (CH) | 1999-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240034739-A1 | PROCESSES FOR MAKING BICYCLIC KETONE COMPOUNDS | HSD17B7, BCKDK, CYP11B1 | KMT2A 1607/4885NPC1 331/4885MEN1 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.